Microglial Dysregulation and Suicidality: A Stress-Diathesis Perspective
نویسندگان
چکیده
منابع مشابه
Microglial Dysregulation in Psychiatric Disease
Microglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain. More recently, they have been shown to have a number of important roles beyond immune surveillance and response, including synaptic pruning during development and the support of adult neurogenesis. Microglial abnormalities h...
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There is accumulating evidence that immune dysregulation contributes to the pathophysiology of obsessive-compulsive disorder (OCD), Tourette syndrome, and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). The mechanistic details of this pathophysiology, however, remain unclear. Here we focus on one particular component of the immune system: micro...
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ژورنال
عنوان ژورنال: Frontiers in Psychiatry
سال: 2020
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2020.00781